Hodgkin Huxley App

Pre-Clamp Duration(ms):

Clamp Duration(ms):

Post-Clamp Duration(ms):

Time steps(ms):

Applied current (0-4 uAmp):

Applied voltage(-10-50 mV):

Membrane Capacitance ( mF):

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Concentration of Sodium Inside (0-1 M)

Concentration of Sodium outside (0-1 M):

Concentration of Potassium Inside(0-1 M):

Concentration of Potassium outside(0-1 M):

Concentration of Chlorine Inside(0-1 M):

Concentration of Chlorine outside(0-1 M):

Concentration of Calcium Inside(0-0.00001 M):

Concentration of Calcium outside(0-0.0001 M):

Total Conductance of Sodium channel (0-2 Si ):

Total Conductance of Potassium channel (0-2 Si):

Total Conductance of Chlorine channel(0-2 Si):

Total Conductance of A channel (0-0.1 Si ):

Total Conductance of M channel (0-0.1 Si):

Total Conductance of AHP channel(0 - 0.1 Si):

Total Conductance of Kca channel(0-0.1 Si):

Total Permeability of CaT channel (0-1 ):

Total Permeability of CaL channel(0-1 ):

Total Conductance of Sodium Leak channel (0-0.01 Si):

Total Conductance of Potassium Leak channel ( 0-0.01 Si):

In 1952 Hodgkin and Huxley published a series of papers, describing the basic processes underlying the nervous mechanisms of control and the communication between nerve cells

For this they received the Nobel prize in physiology and medicine, together with John Eccles in 1963.

Their research was based on electrophysiological experiments carried out in the late 1940s and early 1950 on a giant squid axon to understand how action potentials in neurons are initiated and propagated.

In 1952 Hodgkin and Huxley published a series of papers, describing the basic processes underlying the nervous mechanisms of control and the communication between nerve cells

For this they received the Nobel prize in physiology and medicine, together with John Eccles in 1963.

Their research was based on electrophysiological experiments carried out in the late 1940s and early 1950 on a giant squid axon to understand how action potentials in neurons are initiated and propagated.

Change the parameters below and have fun playing !!!

The full forms of the channels are:

A channel: A-type potassium channel

M channel: M-type potassium channel

AHP: Afterhyperpolarization

Kca: Calcium activated potassium channel

CaT: T-type calcium channel

CaL: L-type calcium channel

Now Try answering these questions

Why does Sodium go down while Potassium go up ?

Why is the leakage current exist ?

Why does the Sodium current have the peculiar spike in the beginning ?

Increase clamp duration to 100 ms and note what happens.

Decrease the conductance of Sodium channel and note what happens.

Increase the applied current and notice the jump in the red line in the current graph after the pre clamp duration.

Developed By Anuj Guruacharya and Binita Rajbanshi

The hosting for this project was provided by the High Performance Computing Center at Oklahoma State University

For educational purposes

Contact us for more features or any ideas

Norman,Oklahoma, USA